Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227451 | 0.86 | KMT2A (0.59) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL7235657 | 0.85 | ALDH1A1 (0.61) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL7226899 | 0.81 | MAPK1 (0.58) | POLBMAPTRAB9AHTTNPSR1 | |
| SCHEMBL7251926 | 0.81 | POLB (0.73) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL1820102 | 0.79 | POLB (0.71) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL9280669 | 0.79 | POLB (0.71) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL4842294 | 0.79 | POLB (0.71) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL3809736 | 0.79 | MAPT (0.82) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL14542532 | 0.78 | POLB (0.69) | POLBHPGDMAPTRAB9AHTT | |
| SCHEMBL1483827 | 0.78 | HPGD (0.72) | POLBHPGDMAPTRAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997040020-A1 | PHTHALAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-10-30 | — | — | WO | disclosed |