Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350854 | 0.86 | POLB (0.68) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL7235657 | 0.85 | ALDH1A1 (0.61) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL7227539 | 0.85 | KMT2A (0.55) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL7227544 | 0.85 | KMT2A (0.55) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL7226899 | 0.81 | MAPK1 (0.58) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL4844039 | 0.79 | MAPT (0.63) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL29379915 | 0.79 | MAPT (0.66) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL14740763 | 0.79 | MAPT (0.66) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL3467843 | 0.79 | MAPT (0.67) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL2483717 | 0.78 | LMNA (0.72) | KMT2AMAPTMEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6600036-B2 | Treating diseases of the central nervous system. | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20020052364-A1 | Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2002-05-02 | — | — | US | disclosed |
| EP-0888356-B1 | CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AG (DE) | 2002-03-20 | — | — | EP | disclosed |
| US-6323197-B1 | NON-COMPETITIVE INHIBITING OF THE AMPA RECEPTORS, THESE COMPOUNDS CAN BE USED AS MEDICAMENTS FOR TREATMENT OF THE CENTRAL NERVOUS SYSTEM | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052364-A1 | Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors | GABRE, GABRA2, GABRB2 | KMT2A 1184/4885MAPT 999/4885MEN1 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.