Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 3/20 | 0.41 |
| ▸ | SDC2 | P34741 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381992 | 0.83 | SLC15A2 (0.44) | MMEALDH1A1MMP2MMP7MMP9 | |
| SCHEMBL9830052 | 0.81 | PSMB5 (0.49) | MMEPSMB5 | |
| SCHEMBL9830035 | 0.81 | PSMB5 (0.49) | MMEPSMB5 | |
| SCHEMBL1275443 | 0.80 | OPRM1 (0.46) | MMEPSMB5 | |
| SCHEMBL1674833 | 0.80 | OPRM1 (0.46) | MMEPSMB5 | |
| SCHEMBL17925467 | 0.80 | OPRM1 (0.46) | MMEPSMB5 | |
| Water SCHEMBL1433018 | 0.80 | OPRM1 (0.46) | MME | |
| Water SCHEMBL1433025 | 0.80 | OPRM1 (0.46) | MME | |
| Water SCHEMBL28629638 | 0.80 | OPRM1 (0.46) | MME | |
| SCHEMBL11012831 | 0.80 | MME (0.49) | MMEPSMB5MMP2MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4894437-A | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties | THE UPJOHN COMPANY (US) | 1990-01-16 | — | — | US | claimed |
| EP-0245361-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-11-19 | — | — | EP | claimed |
| WO-1987002986-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-05-21 | — | — | WO | claimed |
| US-4894437-A | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties | THE UPJOHN COMPANY (US) | 1990-01-16 | — | — | US | disclosed |
| EP-0245361-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |
| WO-1987002986-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-05-21 | — | — | WO | disclosed |