Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337700 | 0.86 | HSD17B10 (0.47) | HSD17B10SMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL27426143 | 0.86 | HSD17B10 (0.47) | HSD17B10SMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL115846 | 0.86 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| SCHEMBL894504 | 0.86 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| SCHEMBL28239355 | 0.86 | HSD17B10 (0.47) | HSD17B10SMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL144831 | 0.86 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| Hydrochloric Acid SCHEMBL25198974 | 0.85 | HSD17B10 (0.49) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| SCHEMBL21946826 | 0.85 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| SCHEMBL31436233 | 0.85 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM | |
| SCHEMBL21999448 | 0.84 | HSD17B10 (0.48) | HSD17B10SMN1; SMN2ALDH1A1PDE8BATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741799-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5741792-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623595-A1 | Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |