Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574005 | 1.00 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL29061973 | 0.90 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL29061976 | 0.90 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7999614 | 0.88 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL13016730 | 0.86 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7325901 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8570355 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7366317 | 0.82 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7363289 | 0.82 | PDE4B (0.60) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7395886 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710180-A | TREATING ALLERGIC AND INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0714397-A4 | — | — | 1996-06-26 | — | — | EP | disclosed |
| EP-0714397-A1 | PHENETHYLAMINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1995005386-A1 | PHENETHYLAMINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-23 | — | — | WO | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |