Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381690 | 1.00 | ADRB2 (0.56) | ADRB2ADRB1ADRB3ALDH1A1PPARA | |
| SCHEMBL16648476 | 1.00 | ADRB2 (0.56) | ADRB2ADRB1ADRB3ALDH1A1PPARA | |
| SCHEMBL3821539 | 0.86 | PPARA (0.63) | ADRB2ADRB1ADRB3ALDH1A1PPARA | |
| SCHEMBL18335299 | 0.86 | PPARA (0.63) | ADRB2ADRB1ADRB3ALDH1A1PPARA | |
| SCHEMBL16661377 | 0.86 | ADRB2 (0.53) | ADRB2ADRB1ADRB3ALDH1A1PPARA | |
| SCHEMBL4583546 | 0.83 | ATM (0.66) | ADRB2ADRB1ADRB3PPARAPPARG | |
| SCHEMBL4583548 | 0.83 | ATM (0.66) | ADRB2ADRB1ADRB3PPARAPPARG | |
| SCHEMBL4583537 | 0.83 | ATM (0.66) | ADRB2ADRB1ADRB3PPARAPPARG | |
| SCHEMBL10871529 | 0.82 | ATM (0.46) | ADRB2ADRB1ADRB3PPARAPPARG | |
| SCHEMBL7485377 | 0.82 | ADRB2 (0.53) | ADRB2ADRB1ADRB3ALDH1A1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |