Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 15/20 | 0.60 |
| ▸ | METAP1 | P53582 | 7/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16730492 | 0.88 | METAP2 (0.51) | METAP2METAP1 | |
| SCHEMBL6476379 | 0.84 | METAP2 (0.64) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL6477146 | 0.83 | METAP2 (0.70) | METAP2METAP1CTSS | |
| SCHEMBL7353359 | 0.82 | METAP2 (0.78) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL7356007 | 0.81 | METAP2 (0.76) | METAP2METAP1REN | |
| SCHEMBL7360854 | 0.81 | METAP2 (0.60) | METAP2METAP1REN | |
| SCHEMBL1863098 | 0.80 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL8269724 | 0.80 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1863093 | 0.80 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1863096 | 0.80 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |