Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.75 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | TPH1 | P17752 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490716 | 0.86 | LDHA (1.00) | LDHAPPARGPPARASLC6A4FFAR1 | |
| SCHEMBL2571084 | 0.81 | LDHA (0.83) | LDHAPPARGPPARASLC6A4TPH1 | |
| SCHEMBL165758 | 0.79 | CYP1A2 (0.55) | — | |
| SCHEMBL27454162 | 0.79 | LDHA (0.77) | LDHAPPARGPPARASLC6A4TPH1 | |
| SCHEMBL22923877 | 0.79 | LDHA (0.67) | LDHAPPARGPPARASLC6A4 | |
| SCHEMBL8859816 | 0.78 | LDHA (0.61) | LDHAPPARGPPARASLC6A4FFAR1 | |
| SCHEMBL5746242 | 0.78 | LDHA (0.71) | LDHAPPARGPPARASLC6A4FFAR1 | |
| SCHEMBL10436394 | 0.78 | LDHA (0.76) | LDHAPPARGPPARASLC6A4KMT2A | |
| SCHEMBL6688761 | 0.78 | LDHA (0.76) | LDHAPPARGPPARASLC6A4KMT2A | |
| SCHEMBL9411838 | 0.77 | LDHA (0.75) | LDHAPPARGPPARASLC6A4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095022-A1 | RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002862-A1 | RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-20 | — | — | WO | disclosed |
| EP-0666842-A1 | HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-08-16 | — | — | EP | disclosed |