Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 2/20 | 0.53 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353185 | 0.91 | AVPR2 (0.62) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7351994 | 0.84 | HPGD (0.46) | HPGDSMN1; SMN2NPC1KMT2AALDH1A1 | |
| SCHEMBL27318182 | 0.84 | AVPR2 (0.53) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7352202 | 0.80 | AVPR2 (0.56) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7350319 | 0.78 | AVPR2 (0.64) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL13980487 | 0.76 | AVPR2 (0.58) | AVPR2AVPR1AL3MBTL3L3MBTL1HSD11B1 | |
| SCHEMBL27325426 | 0.76 | AVPR2 (0.54) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7357354 | 0.76 | AVPR2 (0.54) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7346654 | 0.75 | MAPT (0.47) | HPGDSMN1; SMN2NPC1KMT2AALDH1A1 | |
| SCHEMBL7352814 | 0.73 | AVPR2 (0.68) | AVPR2AVPR1ARAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |