Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.64 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352814 | 0.92 | AVPR2 (0.68) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7349938 | 0.86 | LMNA (0.53) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7352773 | 0.84 | RAB9A (0.48) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7348443 | 0.83 | AVPR2 (0.60) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7351785 | 0.83 | AVPR2 (0.60) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7351282 | 0.82 | HPGD (0.57) | RAB9ASMN1; SMN2HPGDNPC1KMT2A | |
| SCHEMBL7353003 | 0.81 | RAB9A (0.68) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7352132 | 0.81 | PDE4A (0.57) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7345789 | 0.80 | AVPR2 (0.50) | AVPR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7350669 | 0.80 | AVPR2 (0.58) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |