Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.52 |
| ▸ | PDE4A | P27815 | 9/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 8/20 | 0.41 |
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976207 | 0.85 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360943 | 0.81 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL71498 | 0.78 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7354873 | 0.74 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL71286 | 0.74 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7987399 | 0.74 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7353304 | 0.73 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1028931 | 0.73 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1389102 | 0.72 | PDE4A (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2910790 | 0.71 | NPC1 (0.53) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |