Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ME1 | P48163 | 3/20 | 0.38 |
| ▸ | ME2 | P23368 | 2/20 | 0.38 |
| ▸ | ME3 | Q16798 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736591 | 0.89 | SIGMAR1 (0.48) | SIGMAR1OPRM1GAAME1ME2 | |
| SCHEMBL737803 | 0.86 | SIGMAR1 (0.47) | SIGMAR1OPRM1USP2KCNH2ADRA1A | |
| SCHEMBL737605 | 0.86 | SIGMAR1 (0.46) | SIGMAR1OPRM1USP2GAAALDH1A1 | |
| SCHEMBL737501 | 0.85 | SIGMAR1 (0.45) | SIGMAR1OPRM1USP2KCNH2GAA | |
| SCHEMBL736347 | 0.84 | SIGMAR1 (0.45) | SIGMAR1OPRM1KCNH2GAAALDH1A1 | |
| SCHEMBL737490 | 0.84 | SIGMAR1 (0.58) | SIGMAR1OPRM1USP2ALDH1A1MAPK1 | |
| SCHEMBL736580 | 0.82 | OPRM1 (0.57) | SIGMAR1OPRM1KCNH2ADRA1ANPY5R | |
| SCHEMBL22594870 | 0.82 | SIGMAR1 (0.85) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL737008 | 0.82 | SIGMAR1 (0.42) | SIGMAR1OPRM1KCNH2GAADRD4 | |
| SCHEMBL17319124 | 0.82 | SIGMAR1 (0.85) | SIGMAR1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | SIGMAR1 11/4885OPRM1 15/4885USP2 3432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.