Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 4/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352711 | 0.83 | ACE (0.53) | KMT2AKLK5ACECMA1 | |
| SCHEMBL4452584 | 0.83 | KLK5 (0.50) | KMT2AKLK5ACECMA1 | |
| SCHEMBL7381851 | 0.83 | MEN1 (0.49) | MEN1KMT2AKLK5ALDH1A1NPC1 | |
| SCHEMBL4455015 | 0.82 | CMA1 (0.49) | MEN1KMT2AKLK5ACECMA1 | |
| SCHEMBL7348146 | 0.81 | MAPK1 (0.51) | KMT2AKLK5ACECMA1 | |
| SCHEMBL7354571 | 0.80 | ACE (0.51) | MEN1KMT2AKLK5ACECTRB1 | |
| SCHEMBL28067688 | 0.78 | ACE (0.56) | MEN1KMT2AKLK5ACECTRB1 | |
| SCHEMBL28067687 | 0.78 | ACE (0.56) | MEN1KMT2AKLK5ACECTRB1 | |
| SCHEMBL3825215 | 0.77 | CMA1 (0.63) | MEN1KMT2AKLK5ALDH1A1ACE | |
| SCHEMBL21748404 | 0.77 | CMA1 (0.63) | MEN1KMT2AKLK5ALDH1A1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |