Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352711 | 0.94 | ACE (0.53) | MAPK1ACEKLK5KMT2ACMA1 | |
| SCHEMBL4452584 | 0.90 | KLK5 (0.50) | MAPK1ACEKLK5KMT2ACMA1 | |
| SCHEMBL4455015 | 0.89 | CMA1 (0.49) | ACEKLK5KMT2ACMA1 | |
| SCHEMBL7355589 | 0.86 | ACE (0.46) | ACEKLK5KMT2ACMA1 | |
| SCHEMBL7357094 | 0.85 | SCN9A (0.46) | MAPK1ACEKLK5RENKMT2A | |
| SCHEMBL7348794 | 0.85 | MAPK1 (0.51) | MAPK1ACEKLK5RENKMT2A | |
| SCHEMBL7354574 | 0.81 | MEN1 (0.47) | ACEKLK5KMT2ACMA1 | |
| SCHEMBL7348141 | 0.79 | MAPK1 (0.61) | MAPK1ACECMA1 | |
| SCHEMBL7352311 | 0.78 | ACE (0.53) | MAPK1ACEKLK5KMT2ACMA1 | |
| SCHEMBL7347210 | 0.77 | GAA (0.46) | ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |