Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11348979 | 0.83 | HRH4 (0.44) | HRH4NOS1NOS2PDE4APDE4B | |
| SCHEMBL7176775 | 0.75 | HRH4 (0.59) | HRH4NOS1NOS2NOS3MEN1 | |
| SCHEMBL11348211 | 0.74 | HRH4 (0.35) | HRH4 | |
| SCHEMBL4419056 | 0.71 | CHRM3 (0.39) | HRH4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL19398339 | 0.70 | MAPT (0.40) | MAPT | |
| SCHEMBL18069714 | 0.68 | HRH4 (0.42) | HRH4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL21573227 | 0.68 | HRH4 (0.39) | HRH4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2118395 | 0.68 | HRH4 (0.39) | HRH4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15458824 | 0.67 | LMNA (0.39) | RAB9AMEN1MAPTKMT2AKDM4E | |
| SCHEMBL15458828 | 0.67 | ASPH (0.38) | HRH4PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027826-A1 | NOVEL PYRIMIDINES, THE PRODUCTION THEREOF AND THEIR USE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-05-18 | — | — | WO | disclosed |