Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.75 |
| ▸ | GAA | P10253 | 5/20 | 0.75 |
| ▸ | RECQL | P46063 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283647 | 0.71 | ALDH1A1 (0.51) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL11283649 | 0.71 | ALDH1A1 (0.51) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL14794314 | 0.71 | ALDH1A1 (0.48) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL2080699 | 0.70 | GRK5 (0.68) | ALDH1A1RECQLMAPTKMT2AMEN1 | |
| SCHEMBL16223359 | 0.70 | MAPT (0.63) | ALDH1A1GAARECQLMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL16245570 | 0.69 | MAPT (0.61) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL11277684 | 0.69 | ALDH1A1 (0.49) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL11043255 | 0.69 | GAA (0.49) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL11277679 | 0.69 | ALDH1A1 (0.49) | ALDH1A1GAARECQLMAPTKMT2A | |
| SCHEMBL11555543 | 0.68 | ITGA4 (0.47) | ALDH1A1GAARECQLMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840888-A | USEFUL IN THE DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| US-5693801-A | ANTICONVULSANTS; ANXIOLYTIC AGENTS; STIMULANTS; TREATMENT OF OVERDOSES OF BENZODIAZEPINES | NEUROGEN CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |
| US-5266698-A | Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1993-11-30 | — | — | US | disclosed |
| WO-1993022314-A1 | CERTAIN ARYL AND CYCLOALKYL FUSED IMIDAZOPYRAZINEDIONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-11-11 | — | — | WO | disclosed |