Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355183 | 0.92 | PDE2A (0.48) | PDE2APOLBALDH1A1 | |
| SCHEMBL2835216 | 0.91 | PDE2A (0.55) | PDE2APOLBHPGDCCNE2CDK4 | |
| SCHEMBL4947310 | 0.86 | PDE2A (0.62) | PDE2APOLBCCNE2CDK4CCND1 | |
| SCHEMBL7356548 | 0.86 | PDE2A (0.40) | PDE2APOLBCCNE2CCNE1CDK2 | |
| SCHEMBL7000731 | 0.85 | PDE2A (0.57) | PDE2APOLBHPGDALDH1A1TP53 | |
| SCHEMBL7356637 | 0.84 | PDE2A (0.40) | PDE2APOLBALDH1A1MAPK1 | |
| SCHEMBL6999184 | 0.84 | PDE2A (0.57) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6023972 | 0.81 | PDE2A (0.52) | PDE2APOLBCCNE2CDK4CCND1 | |
| SCHEMBL7355722 | 0.81 | ADORA3 (0.48) | PDE2APOLBHPGDCCNE2CDK4 | |
| SCHEMBL6023204 | 0.80 | PDE2A (0.51) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107968-B1 | DIHYDRO-[1,2,3]TRIAZOLO-[4,5-D]PYRIMIDIN-7-ONE | BAYER AG (DE) | 2002-11-13 | — | — | EP | disclosed |
| US-6458796-B1 | METHOD OF TREATING CARDIOVASCULAR DISORDERS, THROMBOEMBOLIC DISORDERS AND ISCHAEMIAS, AND UROGENITAL SYSTEM DISORDERS, COMPRISING ADMINISTERING TO MAMMALS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-01 | — | — | US | disclosed |