Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 11/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354927 | 0.92 | PDE2A (0.57) | PDE2APOLBALDH1A1 | |
| SCHEMBL7356548 | 0.84 | PDE2A (0.40) | PDE2APOLBKMT2A | |
| SCHEMBL2835216 | 0.82 | PDE2A (0.55) | PDE2APOLBALDH1A1KMT2A | |
| SCHEMBL7356637 | 0.81 | PDE2A (0.40) | PDE2APOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL2831825 | 0.80 | PDE2A (0.46) | PDE2AKMT2A | |
| SCHEMBL7355722 | 0.79 | ADORA3 (0.48) | PDE2APOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL4947310 | 0.78 | PDE2A (0.62) | PDE2APOLB | |
| SCHEMBL7000731 | 0.77 | PDE2A (0.57) | PDE2APOLBALDH1A1 | |
| SCHEMBL1960594 | 0.77 | PDE2A (0.43) | PDE2APOLBKMT2AMEN1 | |
| SCHEMBL1961181 | 0.76 | ALDH1A1 (0.42) | POLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107968-B1 | DIHYDRO-[1,2,3]TRIAZOLO-[4,5-D]PYRIMIDIN-7-ONE | BAYER AG (DE) | 2002-11-13 | — | — | EP | disclosed |
| US-6458796-B1 | METHOD OF TREATING CARDIOVASCULAR DISORDERS, THROMBOEMBOLIC DISORDERS AND ISCHAEMIAS, AND UROGENITAL SYSTEM DISORDERS, COMPRISING ADMINISTERING TO MAMMALS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-01 | — | — | US | disclosed |