Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | IL1RN | P18510 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349967 | 0.86 | CMA1 (0.52) | KMT2AMEN1CMA1 | |
| SCHEMBL3557442 | 0.83 | HTT (0.60) | KMT2AMEN1L3MBTL1MAPTMAPK1 | |
| SCHEMBL7355350 | 0.83 | TSHR (0.44) | KMT2AMEN1L3MBTL1MAPTMAPK1 | |
| SCHEMBL1827201 | 0.79 | HTT (0.57) | KMT2AMEN1L3MBTL1MAPTMAPK1 | |
| SCHEMBL7352944 | 0.78 | ACE (0.51) | MAPTMAPK1NPSR1NTSR1GAA | |
| SCHEMBL7346506 | 0.78 | MEN1 (0.60) | KMT2AMEN1POLBCCR1GAA | |
| SCHEMBL7346514 | 0.78 | MEN1 (0.60) | KMT2AMEN1POLBCCR1GAA | |
| SCHEMBL6444697 | 0.76 | CTSS (0.59) | KMT2AMEN1NPSR1ALDH1A1IL1RN | |
| SCHEMBL28709400 | 0.75 | HTT (0.53) | KMT2AMEN1L3MBTL1MAPTMAPK1 | |
| SCHEMBL28709401 | 0.75 | HTT (0.53) | KMT2AMEN1L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |