Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354959 | 0.84 | CMA1 (0.45) | KMT2AMEN1ALOX15MAPT | |
| SCHEMBL7355109 | 0.83 | KMT2A (0.54) | KMT2AMEN1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL7417378 | 0.82 | TSHR (0.48) | TSHRKMT2AMEN1ALOX15PREP | |
| SCHEMBL7417381 | 0.82 | TSHR (0.48) | TSHRKMT2AMEN1ALOX15PREP | |
| SCHEMBL30886009 | 0.77 | EPHX1 (0.57) | KMT2AALDH1A1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL5711219 | 0.75 | HSD11B1 (0.44) | TSHRKMT2AMEN1ALOX15PREP | |
| SCHEMBL13738052 | 0.75 | EPHX1 (0.42) | TSHRKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7419142 | 0.74 | KMT2A (0.50) | TSHRKMT2AMEN1PREPALDH1A1 | |
| SCHEMBL7380787 | 0.73 | EPHX1 (0.38) | TSHRKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7417375 | 0.73 | CTSK (0.43) | TSHRKMT2AMEN1PREPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |