Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117134 | 0.93 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL1403849 | 0.93 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL1403848 | 0.93 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL116387 | 0.93 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13638282 | 0.93 | HSD11B1 (0.66) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117996 | 0.90 | HSD11B1 (0.65) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117581 | 0.90 | HSD11B1 (0.67) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117997 | 0.90 | HSD11B1 (0.65) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117580 | 0.90 | HSD11B1 (0.67) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117579 | 0.90 | HSD11B1 (0.67) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138178-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138178-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20110021512-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. | 2011-01-27 | — | — | US | disclosed |
| US-20110021512-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021512-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885CYP2C9 435/4885CYP3A4 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.