SCHEMBL7355352

SCHEMBL7355352

COc1ccc(CCN(CCC(=O)Nc2ccc(OC)c(OC)c2)C(C)C)cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
CYP3A4 P08684 1/20 0.53
GAA P10253 2/20 0.52
ALDH1A1 P00352 2/20 0.52
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
PSMB5 P28074 1/20 0.50
HDAC1 Q13547 3/20 0.49
HDAC2 Q92769 3/20 0.49
PKM P14618 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
EPHX2 P34913 1/20 0.49
BMP1 P13497 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18760165 0.83 NPC1 (0.67) LMNASMN1; SMN2NPC1RAB9AGAA
SCHEMBL7335360 0.82 CYP3A4 (0.62) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7359470 0.80 NPSR1 (0.56) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7321821 0.79 NPC1 (0.52) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7324508 0.78 CYP1A2 (0.49) LMNASMN1; SMN2CYP3A4GAAALDH1A1
SCHEMBL7359166 0.77 CYP3A4 (0.68) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7360114 0.77 CYP3A4 (0.64) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7326215 0.76 CYP3A4 (0.67) LMNASMN1; SMN2NPC1RAB9ACYP3A4
SCHEMBL7323568 0.76 CYP3A4 (0.64) NPC1RAB9ACYP3A4GAAALDH1A1
SCHEMBL21851964 0.75 AAK1 (0.62) LMNASMN1; SMN2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0852142-A1 Diamines in the treatment of arrhythmia SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1998-07-08 EP disclosed
EP-0639973-A1 DIAMINES IN THE TREATMENT OF ARRHYTHMIA SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1995-03-01 EP disclosed
WO-1993023024-A1 DIAMINES IN THE TREATMENT OF ARRHYTHMIA SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1993-11-25 WO disclosed