Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11636916 | 0.85 | SMN1; SMN2 (0.65) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL21852785 | 0.83 | NPC1 (0.64) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL7959722 | 0.82 | NPC1 (0.63) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL7327512 | 0.82 | NPC1 (0.63) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL3970414 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL18760165 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL12659371 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL7959692 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL9079459 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL27892111 | 0.79 | NPC1 (0.71) | SMN1; SMN2NPSR1NPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | CITY OF HOPE (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | CITY OF HOPE | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | TXN, TXN2, TXNRD3 | AAK1 2662/4885SMN1; SMN2 3405/4885NPSR1 4610/4885 |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | TXN, TXN2, TXNRD3 | AAK1 2662/4885SMN1; SMN2 3405/4885NPSR1 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.