Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.62 |
| ▸ | METAP1 | P53582 | 7/20 | 0.62 |
| ▸ | MMP3 | P08254 | 5/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 4/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7354348 | 0.99 | METAP2 (0.61) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL7353859 | 0.93 | METAP2 (0.65) | METAP2METAP1MMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL7361806 | 0.92 | METAP2 (0.63) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL7351829 | 0.85 | METAP2 (0.61) | METAP2METAP1MMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL7355940 | 0.84 | METAP2 (0.60) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL7315728 | 0.84 | METAP2 (0.62) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL6478047 | 0.84 | METAP2 (0.62) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL7354046 | 0.84 | METAP2 (0.65) | METAP2METAP1MMP3MMP1MMP2 | |
| SCHEMBL7358302 | 0.83 | METAP2 (0.65) | METAP2METAP1CNR1 | |
| SCHEMBL5523633 | 0.83 | EPHX1 (0.57) | MMP3MMP1MMP2EPHX1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |