Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.65 |
| ▸ | METAP1 | P53582 | 7/20 | 0.65 |
| ▸ | CNR1 | P21554 | 6/20 | 0.55 |
| ▸ | CNR2 | P34972 | 4/20 | 0.55 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | LAP3 | P28838 | 2/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7359721 | 0.99 | METAP2 (0.63) | METAP2METAP1CNR1CNR2BCHE | |
| SCHEMBL7353859 | 0.85 | METAP2 (0.65) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7361806 | 0.84 | METAP2 (0.63) | METAP2METAP1 | |
| SCHEMBL7355387 | 0.83 | METAP2 (0.62) | METAP2METAP1CNR1 | |
| Hydrochloric Acid SCHEMBL7354348 | 0.82 | METAP2 (0.61) | METAP2METAP1CNR1 | |
| SCHEMBL10305552 | 0.80 | CNR1 (0.54) | CNR1CNR2BCHE | |
| SCHEMBL7354371 | 0.80 | METAP2 (0.70) | METAP2METAP1 | |
| SCHEMBL7350315 | 0.79 | METAP2 (0.77) | METAP2METAP1 | |
| SCHEMBL7354046 | 0.79 | METAP2 (0.65) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7356659 | 0.79 | METAP2 (0.69) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |