Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 6/20 | 0.59 |
| ▸ | MMP8 | P22894 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 2/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.59 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.55 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509338 | 1.00 | MMP9 (0.59) | MMP9MMP8MMP13ADAMTS4NAALAD2 | |
| SCHEMBL6670868 | 1.00 | MMP9 (0.59) | MMP9MMP8MMP13ADAMTS4NAALAD2 | |
| SCHEMBL1329533 | 0.86 | SLC1A3 (0.56) | MMP9MMP8MMP13SLC1A3SLC1A2 | |
| SCHEMBL4058881 | 0.85 | SLC1A3 (0.55) | MMP9MMP8MMP13SLC1A3SLC1A2 | |
| SCHEMBL6671271 | 0.84 | SLC1A3 (0.57) | MMP9MMP8MMP13ADAMTS4SLC1A3 | |
| SCHEMBL6671273 | 0.84 | SLC1A3 (0.57) | MMP9MMP8MMP13ADAMTS4SLC1A3 | |
| SCHEMBL12044849 | 0.84 | SLC1A3 (0.54) | MMP9MMP8MMP13SLC1A3SLC1A2 | |
| SCHEMBL2820939 | 0.83 | SLC1A3 (0.59) | MMP9MMP8MMP13ADAMTS4SLC1A3 | |
| SCHEMBL6093215 | 0.83 | ITGB3 (0.67) | MMP9MMP8MMP13ADAMTS4SLC1A3 | |
| SCHEMBL7402563 | 0.83 | SLC1A3 (0.59) | MMP9MMP8MMP13ADAMTS4SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5955576-A | PEPTIDE ALDEHYDE ANALOGS THAT INHIBIT THROMBIN OR FACTOR XA; FOR PREVENTION OR TREATMENT OF ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0765338-B1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5883107-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1999-03-16 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0765338-A1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995035312-A1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |