Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR4 | O00206 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355908 | 0.91 | PRMT1 (0.62) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL7355906 | 0.91 | PRMT1 (0.62) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL17583850 | 0.85 | PRMT1 (0.69) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL17583849 | 0.85 | PRMT1 (0.69) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL7361871 | 0.82 | TLR4 (0.49) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL7361868 | 0.82 | TLR4 (0.49) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5733568 | 0.80 | PRMT1 (0.76) | PRMT1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL7990689 | 0.78 | MAPT (0.63) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL7353840 | 0.78 | MAPT (0.63) | ALDH1A1LMNAMAPTHPGDNPC1 | |
| SCHEMBL1011167 | 0.78 | PRMT1 (1.00) | PRMT1ALDH1A1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |