Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.49 |
| ▸ | TLR2 | O60603 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361868 | 1.00 | TLR4 (0.49) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL7355432 | 0.82 | PRMT1 (0.62) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL7355908 | 0.80 | PRMT1 (0.62) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL7355906 | 0.80 | PRMT1 (0.62) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL27947570 | 0.77 | CCNB2 (0.63) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL16499818 | 0.74 | ALDH1A1 (0.60) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL16499817 | 0.74 | ALDH1A1 (0.60) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL8002601 | 0.74 | ALDH1A1 (0.64) | TLR4TLR2MAPTALDH1A1NPSR1 | |
| SCHEMBL8239675 | 0.74 | MEN1 (0.49) | HPGDMEN1KMT2ACCNB2CDK1 | |
| SCHEMBL7353840 | 0.73 | MAPT (0.63) | TLR4TLR2MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |