Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22209502 | 0.91 | NPC1 (0.46) | ELANEMEN1KMT2ANPC1 | |
| SCHEMBL18619641 | 0.91 | NPC1 (0.46) | ELANEMEN1KMT2ANPC1 | |
| SCHEMBL20484718 | 0.87 | MEN1 (0.53) | ELANECMA1MEN1KMT2ANPC1 | |
| SCHEMBL3177023 | 0.87 | MEN1 (0.53) | ELANECMA1MEN1KMT2ANPC1 | |
| SCHEMBL8087773 | 0.83 | LMNA (0.50) | ELANECMA1MEN1KMT2A | |
| SCHEMBL3470215 | 0.83 | LMNA (0.50) | ELANECMA1MEN1KMT2A | |
| SCHEMBL10573052 | 0.82 | ELANE (0.51) | ELANECMA1 | |
| SCHEMBL714622 | 0.81 | NPC1 (0.46) | KMT2ANPC1 | |
| SCHEMBL717020 | 0.81 | PREP (0.62) | — | |
| SCHEMBL717019 | 0.81 | PREP (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743953-A1 | DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021855-A1 | DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |