Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | CMA1 | P23946 | 6/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352711 | 0.90 | ACE (0.53) | ACEKLK5SCN9ACMA1F2 | |
| SCHEMBL7357094 | 0.88 | SCN9A (0.46) | ACEKLK5SCN9ACMA1F2 | |
| SCHEMBL7348146 | 0.86 | MAPK1 (0.51) | ACEKLK5CMA1KMT2A | |
| SCHEMBL4452584 | 0.84 | KLK5 (0.50) | ACEKLK5CMA1KMT2A | |
| SCHEMBL4455015 | 0.83 | CMA1 (0.49) | ACEKLK5CMA1KMT2A | |
| SCHEMBL7355585 | 0.82 | F2 (0.54) | ACEKLK5CMA1F2PRSS1 | |
| SCHEMBL7354574 | 0.78 | MEN1 (0.47) | ACEKLK5CMA1KMT2A | |
| SCHEMBL10826434 | 0.77 | CMA1 (0.58) | ACECMA1F2PRSS1 | |
| SCHEMBL10826474 | 0.77 | CMA1 (0.58) | ACECMA1F2PRSS1 | |
| SCHEMBL7352311 | 0.76 | ACE (0.53) | ACEKLK5SCN9ACMA1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |