Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.77 |
| ▸ | DRD2 | P14416 | 5/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.75 |
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351612 | 0.93 | ACHE (0.80) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL1545611 | 0.90 | ACHE (0.93) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL791116 | 0.88 | ACHE (0.77) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL7351897 | 0.88 | ACHE (0.91) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL3122834 | 0.88 | ACHE (0.77) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL1544799 | 0.88 | ACHE (0.77) | ACHEDRD2SLC6A4HTR2AKCNH2 | |
| SCHEMBL7353484 | 0.88 | ACHE (0.76) | ACHEDRD2SLC6A4HTR2AKCNH2 | |
| SCHEMBL1545556 | 0.87 | ACHE (0.75) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL1544617 | 0.87 | ACHE (0.75) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL1836420 | 0.87 | ACHE (0.75) | ACHEDRD2SLC6A4HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | claimed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | claimed |