Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 12/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502327 | 0.85 | AKT3 (0.35) | AKT3 | |
| SCHEMBL6502329 | 0.81 | AKT3 (0.35) | AKT3SIRT2SIRT1SIRT3 | |
| SCHEMBL6502332 | 0.80 | AKT3 (0.33) | AKT3MAPTSIRT2SIRT1SIRT3 | |
| SCHEMBL7452371 | 0.76 | HPGD (0.52) | ALDH1A1MAPTACKR3 | |
| SCHEMBL7456483 | 0.73 | ACKR3 (0.43) | AKT3ACKR3 | |
| SCHEMBL6503512 | 0.73 | SYK (0.41) | ALDH1A1 | |
| SCHEMBL7453315 | 0.72 | HPGDS (0.37) | AKT3ACKR3 | |
| SCHEMBL6494160 | 0.71 | GRIN3B (0.41) | AKT3 | |
| SCHEMBL6494179 | 0.70 | ITGB3 (0.42) | — | |
| SCHEMBL7456462 | 0.68 | ITGB3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091952-A1 | THIOPHENE AND FURAN 2,5-DICARBOXAMIDES USEFUL IN THE TREATMENT OF CANCER | BIOCHEM PHARMA INC (CA) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000486-A1 | THIOPHENE AND FURAN 2,5-DICARBOXAMIDES USEFUL IN THE TREATMENT OF CANCER | BIOCHEM PHARMA INC. (US) | 2000-01-06 | — | — | WO | disclosed |