Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 7/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356132 | 1.00 | F2 (0.51) | F2GAARENATML3MBTL1 | |
| SCHEMBL7380816 | 0.93 | REN (0.48) | F2GAARENATML3MBTL1 | |
| SCHEMBL7349617 | 0.91 | OPRM1 (0.48) | F2ACEACE2OPRM1OPRD1 | |
| SCHEMBL7349627 | 0.91 | OPRM1 (0.48) | F2ACEACE2OPRM1OPRD1 | |
| SCHEMBL7348394 | 0.87 | ELANE (0.46) | F2RENACEACE2OPRM1 | |
| SCHEMBL7347204 | 0.86 | OPRM1 (0.49) | GAAACEACE2OPRM1OPRD1 | |
| SCHEMBL7348952 | 0.85 | CAPN1 (0.57) | OPRM1OPRD1OPRK1TACR1 | |
| SCHEMBL7348938 | 0.85 | CAPN1 (0.57) | OPRM1OPRD1OPRK1TACR1 | |
| SCHEMBL7352316 | 0.83 | F2 (0.59) | F2RENACE | |
| SCHEMBL7352303 | 0.83 | F2 (0.59) | F2RENACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |