Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 2/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358619 | 0.85 | ADORA3 (0.60) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11003352 | 0.84 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11002932 | 0.83 | CACNA1F (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7275646 | 0.82 | CACNA1F (0.71) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11002983 | 0.81 | CACNA1F (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9085072 | 0.81 | CACNA1F (0.73) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7367434 | 0.81 | KDM4E (0.49) | HIF1AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL7445582 | 0.80 | HIF1A (0.59) | CACNA1FCACNA1DCACNA1SCACNA1CHIF1A | |
| SCHEMBL11843543 | 0.80 | CACNA1F (0.60) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11007284 | 0.79 | CACNA1F (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| EP-0541634-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |