Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358485 | 0.89 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL7356152 | 0.81 | CACNA1F (0.62) | POLBLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7362882 | 0.81 | NR1I2 (0.64) | KDM4EALDH1A1HSD17B10HPGDNR1I2 | |
| SCHEMBL7358619 | 0.80 | ADORA3 (0.60) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL3006534 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10HPGDNR1I2 | |
| SCHEMBL7390505 | 0.77 | MAPT (0.56) | KDM4EHSD17B10POLBTSHR | |
| SCHEMBL9500152 | 0.75 | TSHR (0.51) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL29676206 | 0.74 | NR1I2 (0.73) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL3034560 | 0.74 | NR1I2 (0.73) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL7414856 | 0.73 | NR1I2 (0.67) | KDM4EALDH1A1HSD17B10HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |