Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361535 | 0.83 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL23846999 | 0.80 | KDM4E (0.43) | GABRG2GABRB3GABRA5POLBALDH1A1 | |
| SCHEMBL7356851 | 0.78 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7349414 | 0.73 | GABRG2 (0.39) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7351763 | 0.69 | STAT3 (0.44) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7359720 | 0.67 | KDM4E (0.62) | POLBALDH1A1MAPK1HTTMAPT | |
| SCHEMBL7351990 | 0.67 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL15537304 | 0.64 | POLB (0.48) | POLBALDH1A1HTTMAPTPKM | |
| SCHEMBL16348916 | 0.63 | — | — | |
| SCHEMBL7353193 | 0.63 | GABRG2 (0.70) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |