Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982867 | 0.87 | ACHE (0.62) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL7354058 | 0.80 | KDM4E (0.40) | KDM4EACHEALDH1A1CYP1A2BRD4 | |
| SCHEMBL7354063 | 0.80 | KDM4E (0.40) | KDM4EACHEALDH1A1CYP1A2BRD4 | |
| SCHEMBL14142398 | 0.79 | ACHE (0.76) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL7351763 | 0.78 | STAT3 (0.44) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL9036025 | 0.77 | KDM4E (1.00) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL31321876 | 0.77 | KDM4E (1.00) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL8740800 | 0.76 | KDM4E (0.55) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL23023380 | 0.74 | KDM4E (0.81) | KDM4EACHEALDH1A1HPGDGLA | |
| SCHEMBL9457818 | 0.74 | KDM4E (0.81) | KDM4EACHEALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |