Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16813073 | 0.92 | HTT (0.47) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL29966470 | 0.86 | KDM4E (0.51) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL22026425 | 0.85 | GGPS1 (0.44) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL719201 | 0.83 | HTT (0.43) | KDM4ETDP1MAPK1HTTPOLB | |
| SCHEMBL718257 | 0.83 | HTT (0.43) | KDM4ETDP1MAPK1HTTPOLB | |
| SCHEMBL14619487 | 0.83 | PLA2G1B (0.35) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL16813072 | 0.82 | ALDH1A1 (0.42) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL22840030 | 0.82 | ALDH1A1 (0.42) | KDM4ETDP1MAPK1MEN1KMT2A | |
| SCHEMBL14288365 | 0.82 | MEN1 (0.42) | KDM4EMAPK1MEN1KMT2AHTT | |
| SCHEMBL13991599 | 0.82 | MEN1 (0.42) | KDM4EMAPK1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922703-A | USEFUL FOR TREATING CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0720617-B1 | NOVEL URETHANE-CONTAINING AMINOSTEROID COMPOUNDS | PROCTER & GAMBLE (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0720617-A1 | NOVEL URETHANE-CONTAINING AMINOSTEROID COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008559-A1 | NOVEL URETHANE-CONTAINING AMINOSTEROID COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-30 | — | — | WO | disclosed |