Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.71 |
| ▸ | METAP1 | P53582 | 6/20 | 0.71 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.38 |
| ▸ | IL1RN | P18510 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450230 | 1.00 | METAP2 (0.71) | METAP2METAP1DPP7DPP8BIRC2 | |
| Hydrochloric Acid SCHEMBL7571887 | 0.99 | METAP2 (0.69) | METAP2METAP1DPP7DPP8BIRC2 | |
| Hydrochloric Acid SCHEMBL7571895 | 0.99 | METAP2 (0.69) | METAP2METAP1DPP7DPP8BIRC2 | |
| Hydrochloric Acid SCHEMBL7358093 | 0.99 | METAP2 (0.69) | METAP2METAP1DPP7DPP8BIRC2 | |
| SCHEMBL7576711 | 0.83 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL7352220 | 0.83 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL7576706 | 0.83 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL7356220 | 0.83 | METAP2 (1.00) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7355988 | 0.82 | METAP2 (0.97) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7355595 | 0.82 | METAP2 (0.97) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |