Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 1.00 |
| ▸ | METAP1 | P53582 | 12/20 | 1.00 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576711 | 1.00 | METAP2 (1.00) | METAP2METAP1PPID | |
| SCHEMBL7356220 | 1.00 | METAP2 (1.00) | METAP2METAP1PPID | |
| SCHEMBL7352220 | 1.00 | METAP2 (1.00) | METAP2METAP1PPID | |
| Hydrochloric Acid SCHEMBL7355595 | 0.99 | METAP2 (0.97) | METAP2METAP1PPID | |
| Hydrochloric Acid SCHEMBL7355988 | 0.99 | METAP2 (0.97) | METAP2METAP1PPID | |
| SCHEMBL7446898 | 0.88 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL7361480 | 0.88 | METAP2 (1.00) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7360916 | 0.86 | METAP2 (0.97) | METAP2METAP1 | |
| SCHEMBL7356309 | 0.83 | METAP2 (0.71) | METAP2METAP1 | |
| SCHEMBL7450230 | 0.83 | METAP2 (0.71) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |