Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.53 |
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965418 | 0.93 | MAOB (0.63) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL30443578 | 0.93 | MAOB (0.63) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL25920602 | 0.90 | MAOB (0.64) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL25920598 | 0.89 | MAPT (0.62) | ARMAOBMAPTMEN1KMT2A | |
| Hydroquinone SCHEMBL29014236 | 0.87 | MAOB (0.61) | ARMAOBMAPTMEN1KMT2A | |
| Acetonitrile SCHEMBL28336082 | 0.85 | MAOB (0.62) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL2872357 | 0.84 | MEN1 (0.58) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL6599866 | 0.84 | MAOB (0.68) | ARMAOBMAPTMEN1KMT2A | |
| SCHEMBL18304358 | 0.83 | MAOB (0.62) | MAOBMAPTMEN1KMT2ALMNA | |
| SCHEMBL4747135 | 0.82 | MAPT (0.55) | ARMAOBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101133026-B | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE | 2011-07-06 | — | — | CN | disclosed |
| CN-101133026-A | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | CN | disclosed |
| EP-1054877-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041246-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |