SCHEMBL7356799

SCHEMBL7356799

CCC(O)c1ccnc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 9/20 0.45
LOXL2 Q9Y4K0 1/20 0.44
NCF1 P14598 1/20 0.43
HTR1A P08908 2/20 0.42
ADRA1D P25100 2/20 0.42
ADRA1A P35348 2/20 0.42
ADRA1B P35368 2/20 0.42
LMNA P02545 1/20 0.41
OPRD1 P41143 1/20 0.40
CYP2C19 P33261 3/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
HIF1A Q16665 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NPC1 O15118 1/20 0.39
ESR1 P03372 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6847984 0.88 KDM4E (0.44) CYP2D6HTR1ALMNACYP2C19ALDH1A1
SCHEMBL6665709 0.84 LOXL2 (0.55) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL11904339 0.84 LOXL2 (0.46) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL14532288 0.84 LOXL2 (0.48) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL24700723 0.81 LOXL2 (0.46) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL277463 0.81 LOXL2 (0.50) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL7021926 0.81 LOXL2 (0.46) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL14431011 0.80 NCF1 (0.47) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL19272107 0.80 NCF1 (0.47) CYP2D6LOXL2NCF1HTR1AADRA1D
SCHEMBL1496311 0.80 NCF1 (0.47) CYP2D6LOXL2NCF1HTR1AADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027332-A1 NOVEL LACTAM METALLOPROTEASE INHIBITORS Du Pont Pharmaceuticals Company (US) 2000-08-16 EP disclosed
US-6057336-A ANTIINFLAMMATORY AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-05-02 US disclosed
WO-1999018074-A1 NOVEL LACTAM METALLOPROTEASE INHIBITORS Britol-Myers Squibb Pharma Company (US) 1999-04-15 WO disclosed