Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362798 | 0.82 | POLB (0.39) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7454505 | 0.64 | MAPK1 (0.46) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7440362 | 0.63 | MAPK1 (0.38) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7357903 | 0.62 | POLB (0.40) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL25664507 | 0.62 | GAA (0.57) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL12957011 | 0.62 | MAPK1 (0.78) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7356439 | 0.61 | ALDH1A1 (0.44) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5398985 | 0.59 | MAPK1 (0.64) | MAPK1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL16880117 | 0.59 | KMT2A (0.44) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7374513 | 0.59 | MAPK1 (0.47) | MAPK1KMT2AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117660-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1117660-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018762-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-04-06 | — | — | WO | disclosed |