Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356808 | 0.82 | MAPK1 (0.44) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7357903 | 0.77 | POLB (0.40) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7356989 | 0.71 | POLB (0.41) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5468196 | 0.63 | LMNA (0.41) | POLBKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL30433473 | 0.63 | POLB (0.66) | POLBKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL7012269 | 0.63 | GRIN2D (0.48) | POLBSMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL7010702 | 0.62 | GRIN2D (0.48) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL9268773 | 0.62 | POLB (0.71) | POLBKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4717450 | 0.62 | POLB (0.50) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7364213 | 0.61 | KMT2A (0.50) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117660-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1117660-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018762-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-04-06 | — | — | WO | disclosed |