Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555091 | 0.91 | NPC1 (0.53) | NPC1RAB9ACASP3SENP7SMN1; SMN2 | |
| SCHEMBL6073307 | 0.86 | MAPK1 (0.55) | NPC1RAB9ACASP3SENP7SMN1; SMN2 | |
| SCHEMBL7362324 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7361164 | 0.80 | PDE4B (0.66) | NPC1RAB9ACASP3SENP7PDE4B | |
| SCHEMBL1030016 | 0.80 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7354089 | 0.79 | PDE4B (0.45) | SMN1; SMN2KDM4EALDH1A1PDE4BTSHR | |
| SCHEMBL7363537 | 0.79 | ALDH1A1 (0.50) | NPC1RAB9ACASP3SENP7SMN1; SMN2 | |
| SCHEMBL2934121 | 0.77 | KDM4E (0.51) | NPC1RAB9ACASP3SENP7KDM4E | |
| SCHEMBL9068671 | 0.76 | CA12 (0.59) | RAB9APDE4BTSHRLMNAHTT | |
| SCHEMBL17908114 | 0.76 | PTGER1 (0.56) | NPC1RAB9ACASP3SENP7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |