SCHEMBL7356993

SCHEMBL7356993

CC(=O)Cc1cc(F)cc(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.49
RXRB P28702 3/20 0.49
RXRG P48443 3/20 0.49
CYP3A4 P08684 6/20 0.44
ALDH1A1 P00352 1/20 0.44
TACR1 P25103 3/20 0.40
HTT P42858 1/20 0.40
IDO1 P14902 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39
LMNA P02545 1/20 0.38
KDM4E B2RXH2 1/20 0.38
TSHR P16473 1/20 0.38
CES2 O00748 1/20 0.38
GPR52 Q9Y2T5 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6492340 0.89 IDO1 (0.48) RXRARXRBRXRGTACR1IDO1
SCHEMBL153296 0.84 RXRA (0.67) RXRARXRBRXRGCYP3A4ALDH1A1
SCHEMBL1798610 0.82 MEN1 (0.45) CYP3A4IDO1CES2
SCHEMBL12301741 0.82 TACR1 (0.40) RXRARXRBRXRGTACR1IDO1
SCHEMBL5389064 0.82 RXRA (0.49) RXRARXRBRXRGCYP3A4ALDH1A1
SCHEMBL17790719 0.81 TACR1 (0.46) RXRARXRBRXRGCYP3A4ALDH1A1
SCHEMBL1295226 0.81 HSP90AB1 (0.50) RXRARXRBRXRGCYP3A4ALDH1A1
Hydrochloric Acid SCHEMBL5394073 0.81 RXRA (0.48) RXRARXRBRXRGCYP3A4ALDH1A1
SCHEMBL16959565 0.78 RXRA (0.39) RXRARXRBRXRGCYP3A4ALDH1A1
SCHEMBL5670894 0.78 CYP3A4 (0.56) CYP3A4ALDH1A1TACR1HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1152759-A2 METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2001-11-14 EP disclosed
WO-2000047194-A9 METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR DIMENSIONAL PHARM INC (US) 2001-05-31 WO disclosed
EP-1054886-A1 HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-11-29 EP disclosed
WO-2000047194-A2 METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-08-17 WO disclosed
WO-1999040088-A1 HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1999-08-12 WO disclosed