Sugi Predict

Sugi Predict / Compounds / SCHEMBL153296

SCHEMBL153296

SCHEMBL153296

O=C(O)Cc1cc(F)cc(C(F)(F)F)c1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 9/20 0.67
▸ RXRG P48443 9/20 0.67
▸ RXRB P28702 8/20 0.67
▸ PSEN1 P49768 1/20 0.47
▸ PSEN2 P49810 1/20 0.47
▸ APH1B Q8WW43 1/20 0.47
▸ NCSTN Q92542 1/20 0.47
▸ APH1A Q96BI3 1/20 0.47
▸ PSENEN Q9NZ42 1/20 0.47
▸ FFAR4 Q5NUL3 1/20 0.45
▸ TACR1 P25103 3/20 0.43
▸ AGBL2 Q5U5Z8 1/20 0.42
▸ NR3C1 P04150 1/20 0.41
▸ LMNA P02545 1/20 0.40
▸ VNN1 O95497 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL504122 0.88 RXRA (0.68) RXRARXRGRXRBPSEN1PSEN2
SCHEMBL7356993 0.84 RXRA (0.49) RXRARXRGRXRBFFAR4TACR1
SCHEMBL5389064 0.84 RXRA (0.49) RXRARXRGRXRBFFAR4TACR1
Hydrochloric Acid SCHEMBL5394073 0.82 RXRA (0.48) RXRARXRGRXRBFFAR4TACR1
SCHEMBL17310946 0.82 RXRA (0.51) RXRARXRGRXRBFFAR4TACR1
SCHEMBL8512 0.82 AKR1B1 (0.48) RXRARXRGRXRBAGBL2NR3C1
SCHEMBL4494395 0.81 RXRA (0.56) RXRARXRGRXRBPSEN1PSEN2
SCHEMBL2184606 0.80 RXRA (0.54) RXRARXRGRXRBPSEN1PSEN2
SCHEMBL17147284 0.80 RXRA (0.54) RXRARXRGRXRBPSEN1PSEN2
SCHEMBL22773948 0.80 RXRA (0.54) RXRARXRGRXRBPSEN1PSEN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119978757-A PC material based on waste PC car lamp and preparation method thereof 碳中和环保科技(广州)有限公司 2025-05-13 — — CN claimed
CN-119978757-A PC material based on waste PC car lamp and preparation method thereof 碳中和环保科技(广州)有限公司 2025-05-13 — — CN disclosed
US-12281149-B2 Modulators of G-protein coupled receptors CARMOT THERAPEUTICS, INC. (US) 2025-04-22 — — US disclosed
US-20240383960-A1 Modulators of G-Protein Coupled Receptors CARMOT THERAPEUTICS INC. (US) 2024-11-21 — — US disclosed
WO-2024199402-A1 HETEROCYCLIC COMPOUND AS AT2R ANTAGONIST 武汉人福创新药物研发中心有限公司 2024-10-03 — — WO disclosed
CN-118724877-A Heterocyclic compounds as AT2R antagonists 武汉人福创新药物研发中心有限公司 2024-10-01 — — CN disclosed
CN-117980325-A Modulators of G-protein coupled receptors 卡莫特治疗学股份有限公司 2024-05-03 — — CN disclosed
EP-4337682-A2 MODULATORS OF G-PROTEIN COUPLED RECEPTORS Carmot Therapeutics Inc. (US) 2024-03-20 — — EP disclosed
CN-115594683-B Glutaminase GLS1 inhibitor and preparation method and application thereof 杭州禹胜医药科技有限公司 2023-06-16 — — CN disclosed
US-20230151074-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS CARMOT THERAPEUTICS, INC. 2023-05-18 — — US disclosed
EP-1303490-A1 N-OXIDES AS NK1 RECEPTOR ANTAGONIST PRODRUGS OF 4-PHENYL-PYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2003-04-23 — — EP disclosed
US-6479483-B2 3,4,6-SUBSTITUTED PYRIDINE DERIVATIVES USEFUL FOR TREATING DEPRESSION AND PAIN, RESULTING FROM INFLAMMATORY CONDITIONS, SUCH AS MIGRAINE, RHEUMATOID ARTHRITIS, ASTHMA AND INFLAMATORY BOWEL DISEASE; NK1 RECEPTOR ANTAGONIST HOFFMANN-LA ROCHE INC. 2002-11-12 — — US disclosed
US-20020091265-A1 4-phenyl-pyridine derivatives BOS MICHAEL (CA) 2002-07-11 — — US disclosed
US-20020045642-A1 NK-1 receptor active amine oxide prodrugs HOFFMANN-LA ROCHE INC. 2002-04-18 — — US disclosed
WO-2002006236-A1 N-OXIDES AS NK1 RECEPTOR ANTAGONIST PRODRUGS OF 4-PHENYL-PYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 — — WO disclosed
US-6297375-B1 4-phenyl-pyridine derivatives HOFFMANN-LA ROCHE INC. 2001-10-02 — — US disclosed
CN-1270959-A 4-phenyl pyridine derivatives HOFFMANN LA ROCHE (CH) 2000-10-25 — — CN disclosed
EP-1035115-A1 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists F. HOFFMANN-LA ROCHE AG (CH) 2000-09-13 — — EP disclosed
EP-0739336-B1 GEM-DISUBSTITUTED AZACYCLIC TACHYKININ ANTAGONISTS MERCK SHARP & DOHME (GB) 1998-08-26 — — EP disclosed
US-5760018-A Gem-disubstituted azacyclic tachykinin antagonists MERCK SHARP & DOHME LTD. (GB) 1998-06-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240383960-A1 Modulators of G-Protein Coupled Receptors GIPR, GLP1R, GCGR RXRA 462/4885RXRG 417/4885RXRB 382/4885
US-12281149-B2 Modulators of G-protein coupled receptors GIPR, GLP1R, GCGR RXRA 482/4885RXRG 450/4885RXRB 375/4885
US-20020045642-A1 NK-1 receptor active amine oxide prodrugs TACR1, BDKRB1, NPSR1 RXRA 4348/4885RXRG 4315/4885RXRB 4206/4885
US-20020091265-A1 4-phenyl-pyridine derivatives CBR1, CBR3, HCCS RXRA 1857/4885RXRG 1513/4885RXRB 1484/4885
US-20230151074-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS GIPR, GLP1R, GCGR RXRA 482/4885RXRG 450/4885RXRB 375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.