Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 16/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | CTRC | Q99895 | 2/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352708 | 0.91 | F2 (0.61) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL7355585 | 0.87 | F2 (0.54) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL7354216 | 0.87 | KLK5 (0.51) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL7354222 | 0.87 | KLK5 (0.51) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL7348141 | 0.85 | MAPK1 (0.61) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL4452582 | 0.85 | CMA1 (0.65) | F2PRSS1CMA1ACECTRC | |
| SCHEMBL5736095 | 0.84 | ACE (0.51) | F2PRSS1CMA1ACEKLK5 | |
| SCHEMBL4455011 | 0.83 | CMA1 (0.73) | CMA1ACECTRC | |
| SCHEMBL7357094 | 0.82 | SCN9A (0.46) | F2PRSS1CMA1ACEKLK5 | |
| SCHEMBL7870420 | 0.81 | F2 (0.46) | F2PRSS1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |