Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CMA1 | P23946 | 17/20 | 0.59 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | CTRC | Q99895 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352708 | 0.94 | F2 (0.61) | CMA1ACEF2PRSS1CTRC | |
| SCHEMBL4452582 | 0.92 | CMA1 (0.65) | CMA1ACEF2PRSS1CTRC | |
| SCHEMBL4455011 | 0.89 | CMA1 (0.73) | CMA1ACECTRC | |
| SCHEMBL7355585 | 0.86 | F2 (0.54) | CMA1ACEF2PRSS1CTRC | |
| SCHEMBL7348789 | 0.85 | MAPK1 (0.55) | MAPK1CMA1ACEF2PRSS1 | |
| SCHEMBL7348799 | 0.85 | MAPK1 (0.55) | MAPK1CMA1ACEF2PRSS1 | |
| SCHEMBL7357085 | 0.85 | F2 (0.53) | CMA1ACEF2PRSS1CTRC | |
| SCHEMBL7409245 | 0.85 | CMA1 (0.71) | MAPK1CMA1CTRC | |
| SCHEMBL20174030 | 0.85 | ACE (0.67) | MAPK1CMA1ACEF2PRSS1 | |
| SCHEMBL7354571 | 0.84 | ACE (0.51) | CMA1ACEF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |