Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 5/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148899 | 0.88 | ACE (0.63) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL7537159 | 0.88 | ACE (0.63) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL7272846 | 0.85 | ACE (0.59) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL7539511 | 0.85 | ACE (0.59) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL7538363 | 0.85 | ACE (0.59) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL10403794 | 0.85 | ACE (0.56) | ACEKLK5CMA1CTSLF2 | |
| SCHEMBL7354216 | 0.84 | KLK5 (0.51) | ACEKLK5CMA1F2PRSS1 | |
| SCHEMBL7354222 | 0.84 | KLK5 (0.51) | ACEKLK5CMA1F2PRSS1 | |
| SCHEMBL7379690 | 0.84 | ADORA3 (0.57) | ACEKLK5SCN9ACMA1ADORA3 | |
| SCHEMBL7379695 | 0.84 | ADORA3 (0.57) | ACEKLK5SCN9ACMA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933379-B1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO (JP) | 2006-03-22 | — | — | EP | disclosed |
| US-6319902-B1 | TO ACTIVATE THE CENTRAL NERVOUS SYSTEM, SUCH AS, FOR EXAMPLE, SUSTAINED ACETYLCHOLINE RELEASING ACTION, ANTI-RESERPINE ACTION AND LOCOMOTOR INCREMENT | SHIONOGI & CO., LTD. (JP) | 2001-11-20 | — | — | US | disclosed |
| EP-0933379-A1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO., LTD. (JP) | 1999-08-04 | — | — | EP | disclosed |